Endocrine Abstracts

Low-T3 syndrome (euthyroid sick syndrome) develops in critically ill patients. Due to the catabolic state, accompanying critical illnesses, enhanced oxidative damage to macromolecules is expected to occur in subjects suffering from the low-T3 syndrome.The study aimed at evaluating the level of lipid peroxidation products in blood serum, collected from critically ill patients with the low-T3 syndrome and at estimating the ...

Whereas oxidative reactions occur in all tissues and organs, the thyroid gland constitutes such an organ, in which oxidative processes are indispensable for physiological functions. Thus, with additional oxidative abuse caused by several factors, increased oxidative damage to macromolecules may occur in the thyroid. In turn, numerous metabolic reactions occurring in the liver create favourable conditions for huge oxidative stress.Melatonin is a well-know...

Introduction: Obesity does constitute one of the most common modifiable risk factors for cancer. The process of cancerogenesis is associated with the enhanced oxidative stress. Lipid peroxidation (LPO), resulting from oxidative damage to membrane lipids, as well as oxidative damage to DNA, are the most frequently examined processes to evaluate oxidative damage to macromolecules.Aim: The aim of the study was to evaluate the level of oxidative damage to me...

Bivalent iron (Fe2+), which initiates the Fenton reaction (Fe2++H2O2+H+→Fe3++•OH+H2O), is frequently used to experimentally induce oxidative damage to macromolecules. Growth hormone (GH) and the main mediator of its action – insulin-like growth factor-I (IGF-I) – are involved in oxidative processes, lipid peroxidation (LPO) included.The aim of the...

Iron participates in the Fenton reaction (Fe2++H2O2+H+→Fe3++•OH+H2O), the most basic reaction of oxidative stress. This transition metal is required to keep oxidative balance, although iron overload is associated with enhanced oxidative damage and cancer initiation. Growth hormone (GH) and insulin-like growth factor-I (IGF-I) are also involved in oxidative processes, lipid peroxidation incl...

Before the introduction of mandatory salt iodination in 1997 the North-Eastern Region of Poland was known to be a moderate iodine deficiency area. Moreover, it was one of the mostly contaminated regions after the Chernobyl accident in 1986. The aim of our study was to evaluate the descriptive epidemiological features of incident thyroid cancers diagnosed among the residents of this area between 1996 and 2005. The Regional Cancer Surveillance Program was used to collect data on...